An expert from the BBC has raised concerns about the impact of various commonly prescribed antidepressants on weight changes in the UK. Recent research indicates that individuals taking specific antidepressants may experience weight gain of up to 2kg (4.5lbs) within the first two months of treatment, while others may see a weight loss of up to 2.5kg (5.5lbs).
A study conducted by academics from the Institute of Psychiatry, Psychology & Neuroscience at King’s College London evaluated data from 58,534 participants across more than 150 studies comparing 30 different antidepressants with a placebo. The researchers focused on assessing the side effects of these medications within the initial eight weeks of treatment.
During a segment on BBC Morning Live, Dr. Kasim Ahmed emphasized the importance of understanding the context in which antidepressants are prescribed and highlighted that these medications are crucial for managing mood disorders like depression, anxiety, and bipolar affective disorder.
The study revealed significant variations in weight changes, heart rate, and blood pressure among different antidepressants. Dr. Kasim pointed out that certain medications, such as amitriptyline, could lead to weight gain of up to 2kg within the first 12 weeks, while others like sertraline or citalopram might cause weight loss of up to 1kg. Additionally, he highlighted the impact of these medications on heart rate and blood pressure.
In England, approximately 92.6 million antidepressants were prescribed to an estimated 8.89 million patients in 2024/25. Sertraline, a widely used antidepressant, was prescribed to about 2.9 million patients in England during the same period. The drug was associated with a modest weight loss and a decrease in heart rate but showed slight increases in blood pressure.
On the other hand, amitriptyline, a tricyclic antidepressant, was prescribed to 2.2 million patients in England in 2024/25. This medication was linked to weight gain, increased heart rate, and elevated blood pressure. Recommendations suggest using selective serotonin reuptake inhibitors like sertraline as the primary treatment for depression due to lower side effect profiles.
Health experts like Professor Azeem Majeed stress the importance of regular physical health assessments for individuals on antidepressant therapy to monitor potential side effects. They emphasize the significance of informed decision-making regarding the risks and benefits of antidepressant treatment.
Overall, the study findings aim to provide valuable insights for patients and healthcare providers in selecting the most suitable antidepressant based on individual needs. Regular medication reviews and close monitoring are essential to address any changes in response to antidepressant therapy and ensure optimal treatment outcomes.