A recent review indicates that individuals undergoing specific antidepressant treatments may experience weight changes within the initial two months. The study, led by experts from King’s College London, assessed 58,534 participants across more than 150 trials comparing 30 antidepressants with a placebo.
Results highlighted variations in weight, heart rate, and blood pressure. Notably, the antidepressant sertraline showed a weight loss of 0.76kg and a decrease in heart rate. Conversely, amitriptyline users saw an average weight gain of 1.6kg and elevated heart rate and blood pressure levels.
The study underscored differences in physical effects based on the type of antidepressant prescribed, with some medications leading to weight loss while others resulted in weight gain. Researchers emphasized the importance of patient empowerment and informed decision-making in treatment choices.
Experts stressed the significance of shared decision-making between patients and clinicians in mental health care, advocating for personalized treatment approaches. The study’s findings support the need for regular health monitoring during antidepressant therapy to address potential side effects.